Free Content


TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries

Plain Language Summary available

Article first published online: 24 Jun 2019
DOI: 10.1111/bjd.17715

Comment on this article



Comparative, real‐life and long‐term evidence on the effectiveness and safety of phototherapy and systemic therapy in moderate‐to‐severe atopic eczema ( AE ) is limited. Such data must come from well‐designed prospective patient registries. Standardization of data collection is needed for direct comparisons and data pooling.


To reach a consensus on how and when to measure the previously defined domain items of the TRE atment of AT opic eczema ( TREAT ) Registry Taskforce core dataset for research registries for paediatric and adult patients with AE .


Proposals for the measurement instruments were based on recommendations of the Harmonising Outcome Measures for Eczema ( HOME ) initiative, the existing AE database of TREAT germany, systematic reviews of the literature and expert opinions. The proposals were discussed at three face‐to‐face consensus meetings, one teleconference and via e‐mail. The frequency of follow‐up visits was determined by an expert survey.


A total of 16 experts from seven countries participated in the ‘how to measure’ consensus process and 12 external experts were consulted. A consensus was reached for all domain items on how they should be measured by assigning measurement instruments. A minimum follow‐up frequency of initially 4 weeks after commencing treatment, then every 3 months while on treatment and every 6 months while off treatment was defined.


This core dataset for national AE research registries will aid in the comparability and pooling of data across centres and country borders, and enables international collaboration to assess the long‐term effectiveness and safety of phototherapy and systemic therapy used in patients with AE .

What’s already known about this topic?

Comparable, real‐life and long‐term data on the effectiveness and safety of phototherapy and systemic therapy in patients with atopic eczema (AE) are needed. There is a high diversity of outcomes and instruments used in AE research, which require harmonization to enhance comparability and allow data pooling.

What does this study add?

Our taskforce has reached international consensus on how and when to measure core domain items for national AE research registries. This core dataset is now available for use by researchers worldwide and will aid in the collection of unified data.

What are the clinical implications of this work?

The data collected through this core dataset will help to gain better insights into the long‐term effectiveness and safety of phototherapy and systemic therapy in AE and will provide important information for clinical practice. Standardization of such data collection at the national level will also allow direct data comparisons and pooling across country borders (e.g. in the analysis of treatment‐related adverse events that require large patient numbers).

Read moreRead more (PDF)

Share this article




If you want to submit a letter for publication rather than comment on an article please submit through Scholar One:

There are no comments for this article yet.

Recent Tweets


13 Nov 2019

Find out how changing immunosuppressive treatment practices have impacted SCC and BCC cancer risk in organ transplant recipients at #SCC #BCC #organtransplant #epidemiology


13 Nov 2019

RT The British Association of Dermatologists @HealthySkin4All: We are very excited to be planning the launch of a new open access journal, for which we are now looking for an Editor-in-Chief. Full details and information on how to apply for this role can be found here: @BrJDermatol @ced_wiley


13 Nov 2019

RT Dr Katie Farquhar @katiefarquhar: Very interesting article looking at skin cancer trends in transplant recipients from @BrJDermatol


12 Nov 2019

Why has there been a significant reduction in the incidences of both SCC and BCC in organ transplant recipients over the past two decades? #SCC #BCC #organtransplant #epidemiology


12 Nov 2019

RT The British Association of Dermatologists @HealthySkin4All: There is a need for more economic studies which look at the costs and effectiveness of two or more eczema treatments. These types of studies help inform how healthcare resources are used. @BrJDermatol @Wiley_Health @eczemasociety


11 Nov 2019

Join the discussion regarding the definition and clinical implications of palmoplantar pustulosis at #psoriasis #commentary