Antimelanogenic peptides are potentially useful to treat hyperpigmentation, but many peptides have limited application because of high cost and/or low activity.
To identify small and potent peptide inhibitors of cellular melanin synthesis that are useful for cosmetic and medical applications.
A positional scanning synthetic tetrapeptide combinatorial library was used for screening of potentially active peptides. Antimelanogenic activities of the peptide pools and individual peptides were evaluated in B16‐F10 melanoma cells and human epidermal melanocytes treated with alpha‐melanocyte‐stimulating hormone (α‐ MSH ).
Predicted active tetrapeptide sequences were R‐(F/L)‐(C/W)‐(G/R)‐ NH 2. Of the individual tetrapeptides tested, D3 ( RFWG ‐ NH 2) and D5 ( RLWG ‐ NH 2) exhibited high antimelanogenic activities. Tetrapeptide D9 ( FRWG ‐ NH 2) with a sequence identical to that of a portion of α‐ MSH also showed antimelanogenic activity. Of the tripeptides tested, E5 ( FWG ‐ NH 2), E6 ( LWG ‐ NH 2) and E7 ( RWG ‐ NH 2) were relatively more active. Dipeptide F1 ( WG ‐ NH 2) and monopeptide G1 (G‐ NH 2, glycinamide) retained activity, but G2 (Ac‐G‐ NH 2) and G3 (glycine) did not. The antimelanogenic activities of peptides D3, E5, F1 and G1 were verified in α‐ MSH ‐stimulated human epidermal melanocytes. Commercially available G‐ NH 2· HC l suppressed the phosphorylation levels of cAMP ‐responsive element binding protein, protein levels of microphthalmia‐associated transcription factor and tyrosinase,
Small peptides, including glycinamide and tryptophanyl glycinamide, are potent antimelanogenic agents with potential value for the treatment of skin hyperpigmentation.
13 Nov 2019
Find out how changing immunosuppressive treatment practices have impacted SCC and BCC cancer risk in organ transplant recipients at https://t.co/wlvY9C1BnB #SCC #BCC #organtransplant #epidemiology https://t.co/tofI5FYhdu
13 Nov 2019
RT The British Association of Dermatologists @HealthySkin4All: We are very excited to be planning the launch of a new open access journal, for which we are now looking for an Editor-in-Chief. Full details and information on how to apply for this role can be found here: https://t.co/42Fego0m99 @BrJDermatol @ced_wiley https://t.co/RAtLL76qpd
12 Nov 2019
Why has there been a significant reduction in the incidences of both SCC and BCC in organ transplant recipients over the past two decades? https://t.co/9LZepIh0V0 #SCC #BCC #organtransplant #epidemiology https://t.co/7mFJDPG3ch
12 Nov 2019
RT The British Association of Dermatologists @HealthySkin4All: There is a need for more economic studies which look at the costs and effectiveness of two or more eczema treatments. These types of studies help inform how healthcare resources are used. https://t.co/jXK2mF2WQe @BrJDermatol @Wiley_Health @eczemasociety https://t.co/r90pWBEcRK